Demerol 100 mg tablets (Meperidine hydrochloride) belongs to the class of medications known as narcotic analgesics (pain relievers).
Demerol 100 mg tablets (Meperidine hydrochloride) is used to treat moderate-to-severe pain associated with many medical, surgical, obstetrical, and dental procedures.Demerol 100 mg tablets (Meperidine hydrochloride) works to decrease pain by acting on the brain to increase pain tolerance. Demerol 100 mg tablets (Meperidine hydrochloride)works very quickly and will usually begin to relieve pain within 15 minutes.
This medication should not be used to treat chronic pain.
Demerol 100 mg tablets (Meperidine hydrochloride) is contraindicated for use in patients with significant respiratory depression and in patients with acute or severe asthma (e.g., status asthmaticus) in unmonitored care settings or in the absence of resuscitative equipment. Additionally, avoid coadministration with other CNS depressants when possible, as this significantly increases the risk for profound sedation, respiratory depression, coma, and death. Reserve concomitant prescribing of these drugs for use in patients for whom alternative treatment options are inadequate; if concurrent use is necessary, use the lowest effective dosages and minimum treatment durations needed. Monitor patients closely for signs or symptoms of respiratory depression and sedation. In patients with chronic obstructive pulmonary disease (COPD), cor pulmonale, decreased respiratory reserve, hypoxia, hypercapnia, respiratory insufficiency, upper airway obstruction, or preexisting respiratory depression, it is recommended that non-opioid analgesics be considered as alternatives to meperidine, as even usual therapeutic doses may decrease respiratory drive and cause apnea in these patient populations. Extreme caution should also be used in patients with chronic asthma, kyphoscoliosis (a type of scoliosis), hypoxemia, or paralysis of the phrenic nerve. Patients with advanced age, debilitation, or sleep apnea are at an increased risk for the development of respiratory depression associated with meperidine. Use with caution in patients with obesity as this is a risk factor for obstructive sleep-apnea syndrome and/or decreased respiratory reserve. Meperidine should not be used during impaired consciousness or coma, as significant decreases in respiratory drive may lead to adverse intracranial effects from carbon dioxide retention. Respiratory depression, if left untreated, may cause respiratory arrest and death. Symptoms of respiratory depression include a reduced urge to breathe, a decreased respiratory rate, or deep breaths separated by long pauses (a “sighing” breathing pattern). Carbon dioxide retention from respiratory depression may also worsen opioid sedating effects. Careful monitoring and dose titration is required, particularly when CYP450 3A4 inhibitors or inducers are used concomitantly; concurrent use of a CYP3A4 inhibitor or discontinuation of a concurrently used CYP3A4 inducer may increase plasma meperidine concentrations and potentiate the risk of fatal respiratory depression. Management of respiratory depression should include observation, necessary supportive measures, and opioid antagonist use when indicated.
What side effects are possible with this medication?
Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.
The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.
The following side effects have been reported by at least 1% of people taking this medication. Many of these side effects can be managed, and some may go away on their own over time.
Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.
blurred or double-vision or other changes in vision
dizziness, lightheadedness, or feeling faint
false sense of well-being
stomach cramps or pain
Although most of the side effects listed below don’t happen very often, they could lead to serious problems if you do not seek medical attention.
Check with your doctor as soon as possible if any of the following side effects occur:
fast, slow, or pounding heartbeat
feelings of disassociation from reality
hallucinations (hearing or seeing things that aren’t there)
hives, itching, or skin rash
redness or flushing of face
shortness of breath, wheezing, or troubled breathing
signs of urinary retention (e.g., decrease in amount of urine, difficulty urinating, frequent urge to urinate)
swelling of face
Stop taking this medication and seek medical attention immediately if any of the following signs of overdose occur:
signs of serious allergic reaction (e.g., abdominal cramps, difficulty breathing, nausea and vomiting, or swelling of the face and throat)
signs of shock (e.g., cold, da